
Creating accurate claims and billing for advanced diagnostic imaging services is not just an administrative task that you can ignore. It is an integral step that ensures the financial health and operational efficiency of any healthcare facility, particularly those performing complex radiology procedures.
Radiology departments often struggle to navigate these intricacies, leading to a high denial rate and uncompensated care. Therefore, we decided to empower you with knowledge! Yes, with the correct knowledge, you can differentiate between similar imaging codes, such as those with and without contrast, and ensure precision in billing.
This guide is dedicated to discussing an essential magnetic resonance imaging (MRI) procedure code, CPT code 70553. We will cover everything, from explaining its descriptor to billing and reimbursement guidelines.
If you are completely new to this system, check out our complete guide to CPT codes to get familiar with the basics.
So, without further ado, let’s get started.
CPT code 70553 covers Magnetic resonance (e.g., proton) imaging, brain (including brain stem); without contrast material, followed by contrast material(s) and further sequences.
This procedure is a comprehensive diagnostic study. It requires the radiologist to perform two distinct sets of image acquisition:
CPT code 70553 is the gold standard for detailed brain pathology requiring the highest level of diagnostic specificity, as the combination of images provides superior information compared to either sequence alone.
Discussed below are some of the real-world clinical scenarios where CPT code 70553 applies:
Picture a 58-year-old male patient who visits his neurologist complaining of new-onset seizures, persistent headaches, and recent personality changes.
The neurologist suspects an intracranial mass. The physician orders an MRI of the brain with and without contrast because the contrast agent is essential for clearly delineating the margins of a tumor, assessing its vascularity, and determining the presence of surrounding edema. Here, CPT code 70553 applies.
Assume a 35-year-old female patient with a known diagnosis of MS comes for a routine follow-up. She reports new symptoms, including worsening numbness and vision problems. The physician orders CPT 70553.
The non-contrast sequence will identify older lesions (plaques), while the contrast-enhanced sequence will highlight any new, active inflammation, indicating disease progression. This differentiation is critical for treatment planning. In this situation, CPT code 70553 will be reported for accurate reimbursement.
Imagine a 45-year-old patient with a recent history of a systemic infection who develops unexplained fever, severe headache, and signs of increased intracranial pressure. The physician orders a brain MRI with and without contrast to screen for meningitis, encephalitis, or a brain abscess. These infectious processes often cause characteristic “ring-enhancement” on the contrast-enhanced images. CPT code 70553 precisely covers the performed diagnostic study.
What happens when you encounter a situation where the service provided needs to be split between the facility and the interpreting physician? Will the payer pay you for the whole procedure? Reporting CPT 70553 without the appropriate modifier may result in a claim denial or underpayment.
Here are the essential modifiers to know:
For detailed guidance on modifier usage for imaging services, consult resources provided by the American College of Radiology (ACR).
The following are the essential reimbursement and billing requirements for MRI Brain with and without contrast:
You can never unlock a locked door with the wrong key. The payer will never compensate for care services if the procedure is deemed medically unnecessary. Thus, the top requirement to fulfill while billing for CPT code 70553 is to justify its medical necessity. You can do this by using a specific, high-level ICD-10 diagnosis code (e.g., suspected neoplasm, multiple sclerosis, or stroke) that supports the need for contrast.
Comprehensive and accurate documentation is another integral requirement. It directly helps in demonstrating medical necessity. Therefore, your documentation must include the following:
The contrast material itself (e.g., Gadolinium) is typically billed separately using a specific HCPCS Level II code (e.g., Q9967 or A9576), in addition to the CPT code 70553. Do not assume the cost of the material is bundled into the procedure code, check your payer’s policy.
Due to the high cost and complexity of the procedure, CPT 70553 almost universally requires prior authorization from the payer before the service is rendered. Failure to secure this authorization will almost certainly result in a claim denial. Providers should always check the guidelines set by the Centers for Medicare & Medicaid Services (CMS) or relevant commercial payers.
We have covered a lot of ground in this comprehensive guide. So, let’s quickly summarize all key takeaways to reiterate all the critical details related to CPT code 70553.
With all this information, if you still struggle to receive timely reimbursements for your advanced diagnostic imaging procedures, feel free to acquire expert radiology billing services from professionals.




Sign up for my newsletter to see new photos, tips, and blog posts. Do not worry, we will never spam you.

Health Engine Journal is a modern health-focused blog dedicated to delivering clear, reliable, and well-researched information. Our goal is to educate, inspire, and support individuals, professionals, and learners in understanding the evolving world of healthcare. We simplify complex medical and wellness topics into practical knowledge you can trust.